Cell migration

Cell migration

Automatic timing photography records show that the cultured cells can move on the attachment surface, and under low cell density, the fibroblasts have the strongest migration ability (no contact between cells), and the dense monolayer epithelial cells have the weakest migration ability. The cells move individually in a recognizable polar motion. The lamellar pseudopods formed by actin polymerization [Pollard and Borisy, 2003] are attached to the support and extend in the direction of movement. Direct the cell to conduct directional movement. Once the cell meets another cell, the polarity will change and the cell will migrate in reverse. The colloidal gold trace technology shows that [Scott et al., 2000] migration movement is irregular,

When the cell density reaches confluence, migration will stop. The movement stops when the cells are in contact with each other, and the folds of the plasma membrane decrease, and finally the cell division stops. This phenomenon is called contact inhibition. The migration of myoblasts and endothelial cells is similar to fibroblasts. When the cells reach confluence, they rely on the microenvironment to differentiate. The transformed epithelial cells move randomly like polar single cells. At low seeding density, the cultured cells will continue to move until they contact each other. Finally, The cells aggregate into plaques, and the shape and migration of the entire plaque can explain the common movement of cultured cells [Casanova, 2002].

ChangQingShu BabyToy

ChangQingShu BabyToy

ChangQingShu BabyToy

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