"Spirit" rapamycin may help anti-aging
Recently, a study published in the international magazine Aging Cell, researchers from Oregon State University found that rapamycin has unusual properties that may help treat neurological damage in the body, such as Alz Hairy disease, related research may help researchers understand the mechanism of action of rapamycin.
Researcher Viviana Perez said that this study may provide us with a new treatment for neurological diseases. Currently, researchers have identified two mechanisms of action of rapamycin, one of which we already know, A newly discovered mechanism may help to effectively prevent neurological damage and certain related diseases in the body. The value of rapamycin is directly related to cell senescence, a state in which cells age and stop growing. When cells age, they begin to secrete damaging substances, eventually leading to inflammation, while rapamycin can Block the above process.
The secretion of damaged compounds can create a toxic environment called senescence associated secretory phenotype (SASP), which researchers believe may interfere with the microenvironment of cells and alter adjacent cell functions. The normal play, thereby neutralizing its organizational structure and function. Of course, this can ultimately be linked to the body's aging; the researcher Perez pointed out that the increase in cell aging is directly related to the body's aging and inflammation, and this will prepare for a series of degenerative diseases, such as cancer. , heart disease, diabetes, dementia, and Alzheimer's disease; after studying the experimental animals, the researchers found that when the aging cells in the animal's body are removed, the lifespan of these animals will be prolonged, and the prevalence will be obvious. Decreased, and rapamycin also produces a similar effect.
In previous studies, the researchers observed that rapamycin appeared to exhibit only one mechanism of action during this process. The researchers believe that this mechanism can help increase the role of the major regulator Nrf2, while Nrf2 can open more than 200 The expression of genes responsible for cell repair, detoxification of carcinogens, metabolism of proteins and lipids, protection of antioxidants, and other factors, of course, can also help reduce the level of SASP in the process.
In this latest study, the researchers found that rapamycin can also directly affect the level of SASP, which is independent of the Nrf2 pathway, and in this particular way may also affect neurons and other types of cells. Any pathway that helps protect neurons from damage may be valuable. For example, in other studies, researchers have found that SASP can damage astrocytes that protect neuronal function and health, and this also triggers certain Causes of neurodegenerative diseases, including Alzheimer's disease.
Although two pathways (one involving Nrf2 and the other being a more straightforward method) can help inhibit SASP-associated cell damage, rapamycin can still cause scientists tremendously in the study of human body aging. interest of. Rapamycin is a natural compound that was first discovered in the soil of Easter Island in the South Pacific, and researchers have conducted extensive research on it because it mimics the precious effects of dietary restriction, and Rapamycin It also extends the lifespan of certain animals.
The researchers found that laboratory mice receiving rapamycin showed a healthier performance, and their activity decreased more slowly with age, while rapamycin also enhanced cognitive and cardiovascular health in mice. And mice are also less susceptible to cancer and their lifespan will be prolonged. Because rapamycin has certain side effects, its current research in the human body has been limited, which will increase the body's tolerance to insulin, which will undoubtedly increase the risk of diabetes in individuals. Look for analogs of rapamycin that produce biological effects similar to rapamycin without causing unknown side effects.
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