P-hydroxybenzoic acid is promising for development

P-hydroxybenzoic acid, also known as p-cresol formic acid, p-hydroxybenzoic acid, molecular formula C7H6O3, white prismatic crystals, soluble in hot water and ethanol, soluble in ether, acetone, slightly soluble in benzene, insoluble in carbon disulfide, soluble 125 parts cold water. Hydroxybenzoic acid is mainly used as the basic raw material of fine chemical products, and parabens, that is, parabens, are widely used as preservatives for food, medicine and cosmetics. It is also widely used in the preparation of various dyes and sterilization. Agents, color film films, and various oil-soluble color-forming couplers, etc., are also used as basic raw materials for new high-temperature-resistant polymer parahydroxybenzoic polyesters with a wide range of uses.
The preliminary survey conducted on the domestic market shows that the annual demand for this product in domestic related industries is more than 1,500 tons, of which the cosmetics and pharmaceutical industries account for a large proportion, and some manufacturers export a large amount of products. They are mainly used for antiseptic, bactericidal and disinfectants. According to statistics, 39.5% are for cosmetics, 13.2% for food additives, and 47.3% for medicines, fiber raw materials, etc. It is understood that due to the micro-toxicity and non-irritating properties of parabens, the United States has adopted it as the preferred preservative in the cosmetics industry as a statute. In China, only Jiangsu Suining Paint Making Factory, Zhejiang Huangyan Chemical Factory, and Guangzhou Donghu Chemical Factory produced a small amount of production.
At present, the synthesis of this product in the industry has tosyl chloride as raw material, ammoniated, oxidized, salted out, alkali melting, acid precipitation derived; there salicylic acid into salt and re-acidification method. The classical method used more often is a liquid phase method in which a solid phase method of directly reacting with a potassium phenoxide salt and a reaction under the presence of an excess of phenol are used.
Recently, a domestic university developed a product that uses phenol and potassium hydroxide as raw materials, adds the third component, removes water, and passes carbon dioxide to be reacted and purified by post-treatment. The technology uses a complex solvent as the reaction medium and a new post-treatment process. The entire production process adopts a closed-circuit method, which makes the new process have the following features:
(1) The reaction conversion rate, the selectivity is high, the reaction speed is fast, and it is carried out at low pressure.
(2) The post-treatment of the product is simple and the purity of the crude product is more than 98%.
(3) The closed-circuit recycling process makes the total product yield more than 90%.
(4) Elimination of toxic waste gas and wastewater discharge.
At the same time, the industrial installation of this product was studied and succeeded.
It is estimated that this process will be used to build a 200-ton parahydroxybenzoic acid production plant with a total investment of 3.2 million yuan, sales income of 5 million yuan, and annual profit of 1.8 million yuan. The economic benefits are considerable.
P-hydroxybenzoic acid, also known as p-cresol formic acid, p-hydroxybenzoic acid, molecular formula C7H6O3, white prismatic crystals, soluble in hot water and ethanol, soluble in ether, acetone, slightly soluble in benzene, insoluble in carbon disulfide, soluble 125 parts cold water. Hydroxybenzoic acid is mainly used as the basic raw material of fine chemical products, and parabens, that is, parabens, are widely used as preservatives for food, medicine and cosmetics. It is also widely used in the preparation of various dyes and sterilization. Agents, color film films, and various oil-soluble color-forming couplers, etc., are also used as basic raw materials for new high-temperature-resistant polymer parahydroxybenzoic polyesters with a wide range of uses.
The preliminary survey conducted on the domestic market shows that the annual demand for this product in domestic related industries is more than 1,500 tons, of which the cosmetics and pharmaceutical industries account for a large proportion, and some manufacturers export a large amount of products. They are mainly used for antiseptic, bactericidal and disinfectants. According to statistics, 39.5% are for cosmetics, 13.2% for food additives, and 47.3% for medicines, fiber raw materials, etc. It is understood that due to the micro-toxicity and non-irritating properties of parabens, the United States has adopted it as the preferred preservative in the cosmetics industry as a statute. In China, only Jiangsu Suining Paint Making Factory, Zhejiang Huangyan Chemical Factory, and Guangzhou Donghu Chemical Factory produced a small amount of production.
At present, the synthesis of this product in the industry has tosyl chloride as raw material, ammoniated, oxidized, salted out, alkali melting, acid precipitation derived; there salicylic acid into salt and re-acidification method. The classical method used more often is a liquid phase method in which a solid phase method of directly reacting with a potassium phenoxide salt and a reaction under the presence of an excess of phenol are used.
Recently, a domestic university developed a product that uses phenol and potassium hydroxide as raw materials, adds the third component, removes water, and passes carbon dioxide to be reacted and purified by post-treatment. The technology uses a complex solvent as the reaction medium and a new post-treatment process. The entire production process adopts a closed-circuit method, which makes the new process have the following features:
(1) The reaction conversion rate, the selectivity is high, the reaction speed is fast, and it is carried out at low pressure.
(2) The post-treatment of the product is simple and the purity of the crude product is more than 98%.
(3) The closed-circuit recycling process makes the total product yield more than 90%.
(4) Elimination of toxic waste gas and wastewater discharge.
At the same time, the industrial installation of this product was studied and succeeded.
It is estimated that this process will be used to build a 200-ton parahydroxybenzoic acid production plant with a total investment of 3.2 million yuan, sales income of 5 million yuan, and annual profit of 1.8 million yuan. The economic benefits are considerable.

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